Child MRI Study
This research project focuses on mapping the neural and behavioral development of emotional processing in children and adolescents. In particular, we compare normal to abnormal development of emotional processing systems in youth. Participants in our studies are both healthy, typically developing children, and children impacted by depression, anxiety or trauma. We aim to establish patterns of functional responses in human neural networks that support emotional processing in youth. Our approach is to use clinical, behavioral, endocrine (cortisol, testosterone), and genetic and epigenetic data as well as both functional (resting-state and task-based) and structural (DTI) neuroimaging methods to model healthy and atypical brain development.
Swartz, J.R., Thomason, M.E., Wiggins, J.L., Carrasco, M., & Monk, C.S. (2013) Changes in PFC-amygdala connectivity across adolescence: Insights from multiple imaging modalities. Society for Research in Child Development Biennial Meeting Abstracts.
Torrisi, S.J., Moody, T.D., Vizueta, N., Thomason, M.E., Townsend, J.D., Bookheimer, S.Y., & Altshuler, L.L. (2012) Differences in resting corticolimbic functional connectivity in bipolar I euthymia. Bipolar Disorders. Accepted 9-November-2012.
Daher, A.H., Bedway, A.R., Swartz, A.K., Youmans, M., Gardner, M., Swift-Godzsiz, K.L., Kowaleski, K.M., Papiez, K., Goetz, S.M., Carre, J.M., & Thomason, M.E. (2012) Associations between subjective and endocrine stress parameters in youth during an fMRI session. Society for Neuroscience 42nd Annual Meeting Abstracts.
*Monje, M., Thomason, M.E., Rigolo, B.S., Wang, Y., Waber, D.P., Sallan, S.E., & Golby, A.J. (2012) Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of Acute Lymphoblastic Leukemia. Pediatric Blood & Cancer. 60(2):293-300.
*Monje and Thomason are co-first authors.
Schaffhauser, J., Baldwin, G., Lozon, T.A., Rihan, B., Quednau, K.A., Shen, S., Katkuri, Y., Goetz, S., Carre, J.M., Marusak, H.A., & Thomason, M.E. (2012) Hippocampal to default mode network (DMN) neural connectivity corresponds to cortisol levels during MRI in youth. Society for Neuroscience 42nd Annual Meeting Abstracts.
Martin, K., Shen, S., & Thomason, M.E. (2012) Separate neural systems resolve emotional and nonemotional conflict in children. Cognitive Neuroscience Society 19th Annual Meeting Abstracts.
Thomason, M.E., & Thompson, P.M. (2011) Diffusion Imaging, White Matter and Psychopathology. Volume 7 of the Annual Review of Clinical Psychology.
Thomason, M.E., Hamilton, J.P., & Gotlib, I.H. (2011) Stress-induced activation of the HPA axis predicts connectivity between subgenual cingulate and salience network during rest in adolescents. The Journal of Child Psychology and Psychiatry. 52(10):1026-34.
Thomason, M.E., Dennis, E., Joshi, A.A., Joshi, S.H., Dinov, I.D., Chang, C., Henry, M.L., Johnson, R.F., Thompson, P.M., Toga, A.W., Glover, G.H., Van Horn, J.D., & Gotlib, I.H. (2011) Resting-state fMRI can reliably map neural networks in children. NeuroImage. 55(1):165-75.
Thomason, M.E., Tocco, M.A., Quednau, K.A., Bedway, A.R. & Carré, J.M. (in press) Idle behaviors of the hippocampus reflect endogenous cortisol levels in youth. Journal of the American Academy of Child and Adolescent Psychiatry.